Lindane

From Academic Kids

Lindane is an insecticide, also known as gamma-Hexachlorocyclohexane (HCH) and benzene hexachloride (BHC). It has an LD50 of 88 mg/kg, is suspected of being a carcinogen and is banned in the U.S. state of California and in 52 countries.

It's method of action is via interfering with the GABAa receptor/Cl- channel. It is volatile with roughly 90% enering the atmosphere and ultimately being deposited in rain. In 1992 5.5 mg/L of lindane was detected in rain in Oxfordshire. It is till widely used in most of Europe and nearly all developing countries.

Like other agricultural pesticides, lindane is very easily introduced into the water & food supply of an area through rainfall; this can lead to low-level lindane poisoning amongst the local community. A chief symptom of this is a tic causing occasional flickering of the eyelid; other than this minor discomfort, such levels of poisoning are not harmful.

It is sold in a one-percent formulation as Kwell shampoo and lotion (among other brand names, also generically), used to treat human scabies infection, head lice and other ectoparasites. It has recently been banned for the treatment of head lice in California. In the United States, the Food and Drug Administration requires these products be labeled with prominent warnings about possible neurotoxicity, particularly in young patients.


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